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. 2018 Sep 7;8:13438. doi: 10.1038/s41598-018-31680-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PICK1 inhibitor blocks long term depression. Long term depression (LTD) responses from vehicle-treated slices (●) and after treatment with PICK1 inhibitor (compound 1r, 4 µM) () internally before and after low frequency stimulation (LFS). Each point is the Mean ± SEM of 6 slices from 6 animals treated with control, and 9 slices from 7 animals in compound 1r. Inset shows EPSP traces of control slice before (1) and after LFS (2) revealing significant inhibition of LTD in the presence of compound 1r (1 + 2 overlay). EPSC, excitatory post synaptic current.

Inline graphic — PICK1 inhibitor blocks long term depression. Long term depression (LTD) responses from vehicle-treated slices (●) and after treatment with PICK1 inhibitor (compound 1r, 4 µM) () internally before and after low frequency stimulation (LFS). Each point is the Mean ± SEM of 6 slices from 6 animals treated with control, and 9 slices from 7 animals in compound 1r. Inset shows EPSP traces of control slice before (1) and after LFS (2) revealing significant inhibition of LTD in the presence of compound 1r (1 + 2 overlay). EPSC, excitatory post synaptic current.