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. Author manuscript; available in PMC: 2018 Sep 8.
Published in final edited form as: Bioconjug Chem. 2018 Mar 1;29(4):914–927. doi: 10.1021/acs.bioconjchem.7b00816

Figure 3.

Figure 3.

(A) td-Tomato images of liver and subcutaneous tumors on untreated, RA, TAX, and RA-TAX treated mice at day 55. RA-TAX treated mice had the lowest td-Tomato intensity in both cases. (B) RA-TAX filomicelles were efficacious with orthotopic A549 liver tumors, shrinking and arresting the growth of tumors, while single drugs failed to do both. While TAX controlled the growth of tumors, those treated with RA continue to grow. (C) RA-TAX filomicelles shrunk subcutaneous A549 tumors by ~50%. Single drug controls arrest the growth of tumors 30 days from the start of the treatment. During the same time frame, untreated tumors more than double in size. (D) Kaplan−Meier curve showing significant prolonged survival of RA-TAX treated mice A549 liver and subcutaneous tumors.