Table 3.
Activation of ERα in trans-activation assays by PFAAs
| Assay | Chemical | Hit Call 1 | Modeled Maximum 2 | Maximum SD 3 | Modeled AC50 4 | AC50 SD 5 |
|---|---|---|---|---|---|---|
| ATG_ERE_CIS_up | PFNA | 1 | 1.898 | 0.124 | 1.490 | 0.047 |
| PFOS | 1 | 0.707 | 0.070 | 1.257 | 0.069 | |
| PFOA | 1 | 2.034 | 0.029 | 1.529 | 0.007 | |
| PFOS-K | 1 | 1.848 | 0.762 | 1.514 | 0.222 | |
| PFOA, ammonium salt | 1 | 1.708 | 0.052 | 1.356 | 0.013 | |
| PFHS-K | 1 | 1.381 | 0.449 | 1.986 | 0.177 | |
| ATG_ERa_TRANS_up | PFNA | 1 | 2.566 | 0.228 | 1.330 | 0.089 |
| PFOS | 1 | 2.256 | 0.070 | 1.590 | 0.026 | |
| PFOA | 1 | 4.278 | 1.538 | 1.674 | 0.210 | |
| PFOS-K | 1 | 2.159 | 1.683 | 1.555 | 0.397 | |
| PFOA, ammonium salt | 1 | 2.874 | 0.382 | 1.650 | 0.121 | |
| PFHS-K | 0 | NA | NA | NA | NA |
1
= Hit call: 1 = active, 0 = inactive;
2
= top asymptote predicted by model (log10 fold induction);
3
= standard deviation of modeled maximum;
4
= modeled half maximal concentration (log10 μM);
5
= standard deviation of AC50.