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. 2018 Sep 4;13:5059–5073. doi: 10.2147/IJN.S172906

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© 2018 Sudirman et al. This work is published and licensed by Dove Medical Press Limited

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Testis (A) IL-6 and (B) TNF-α and (C) plasma IFN-γ production in STZ-induced diabetic rats fed different doses of Nano-PAC after 42 days.

Notes: Data are shown as mean±SD (n=6 rats/group). The bars with different letters (a and b) represent significant (P<0.05) difference as analyzed by the Duncan’s multiple range test.

Abbreviations: STZ, streptozotocin; Nano-PAC, PAC encapsulated in silica–chitosan nanoparticles; Con, control; DM, diabetes mellitus; Nano-PAC1, diabetes+4 mg/kg per day Nano-PAC; Nano-PAC2, diabetes+8 mg/kg per day Nano-PAC; Nano-PAC5, diabetes+20 mg/kg per day Nano-PAC; Met, diabetes+300 mg/kg per day metformin; Nano-con, diabetes+20 mg/kg per day silica–chitosan nanoparticles; PAC, petri dish-cultured Antrodia cinnamomea.