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. 2018 Sep 4;12:2715–2730. doi: 10.2147/DDDT.S176349

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© 2018 Wei et al. This work is published and licensed by Dove Medical Press Limited

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βE₂ administration reduces apoptosis after blue LED exposure.

Notes: (A) Apoptosis was detected using the TUNEL assay after the intravitreal administration of βE₂ 5 days after blue LED exposure. (B) Statistical analysis of apoptotic cells on retina. (C) Bax, Bcl-2, Caspase-3, Akt and p-Akt protein levels were examined by western blotting. (D) Statistical analysis of western blot. (E) Bax, Bcl-2, Cleaved caspase-3, and p-Akt expression levels were examined by immunohistochemistry. The data represent the mean ± SEM; n=6 (eye samples in each group). ^*P<0.05 vs. control; ^#P<0.05 vs. blue LED.

Abbreviations: βE₂, 17β-estradiol; LED, light-emitting diode.

βE₂ administration reduces apoptosis after blue LED exposure.

Notes: (A) Apoptosis was detected using the TUNEL assay after the intravitreal administration of βE₂ 5 days after blue LED exposure. (B) Statistical analysis of apoptotic cells on retina. (C) Bax, Bcl-2, Caspase-3, Akt and p-Akt protein levels were examined by western blotting. (D) Statistical analysis of western blot. (E) Bax, Bcl-2, Cleaved caspase-3, and p-Akt expression levels were examined by immunohistochemistry. The data represent the mean ± SEM; n=6 (eye samples in each group). ^*P<0.05 vs. control; ^#P<0.05 vs. blue LED.

Abbreviations: βE₂, 17β-estradiol; LED, light-emitting diode.