Figure 5.

NB enhances TMZ-induced anticancer efficiency in vivo.

Notes: NB enhances TMZ-induced inhibition against tumor volume (A) and tumor weight (B). (C) NB enhances TMZ-induced apoptosis and DNA damage. The protein expression was examined by Western blotting methods. (D) NB enhances TMZ-induced anti-proliferation and anti-angiogenesis. The protein expression was examined by IHC methods. Scale bar=50 µm. Bars with different characters indicate the statistical difference at the P<0.05 level. All data and images were obtained from three independent experiments.

Abbreviations: IHC, immunohistochemical; NB, natural borneol; TMZ, temozolomide.