Table 3.
Comparison of postoperative morbidity and mortality between groups
| Morbidity and mortality | COA (n=126) | IOA (n=332) | t/χ2 | P values |
| Anastomotic leakage, % | 21 (16.6) | 34 (10.2) | 3.19 | 0.058 |
| Grade 1 | 3 (2.3) | 7 (2.1) | 0.03 | 0.859 |
| Grade 2 | 13 (10.3) | 18 (5.4) | 3.46 | 0.063 |
| Grade 3 | 5 (4.0) | 9 (2.7) | 0.26 | 0.521 |
| Functional morbidity, % | ||||
| Recurrent laryngeal nerve injury | 13 (10.3) | 4 (1.2) | 21.18 | 0.001 |
| Endoscopy for suspected stricture | 41 (32.5) | 72 (21.7) | 5.78 | 0.016 |
| Stricture requiring dilatation | 25 (19.8) | 45 (13.5) | 4.44 | 0.035 |
| Dysphagia | 44 (34.9) | 69 (20.7) | 3.33 | 0.020 |
| Regurgitation, % | 18 (14.3) | 26 (7.8) | 4.37 | 0.037 |
| Thoracic complications, % | ||||
| Pneumonia | 40 (31.7) | 99 (29.8) | 0.16 | 0.689 |
| Empyema | 10 (7.9) | 28 (8.4) | 0.03 | 0.863 |
| Pneumothorax | 10 (7.9) | 33 (9.9) | 0.43 | 0.512 |
| Mediastinitis | 5 (3.9) | 16 (4.8) | 0.15 | 0.698 |
| Chyle leakage | 8 (6.3) | 26 (7.8) | 0.29 | 0.589 |
| Reintubation rate | 18 (14.3) | 49 (14.8) | 0.02 | 0.898 |
| MACCE, % | ||||
| Sustained arrhythmia | 26 (20.6) | 79 (23.7) | 0.52 | 0.473 |
| Myocardial infarction | 2 (1.6) | 5 (1.5) | 0.001 | 0.950 |
| Cardiac arrest | 1 (0.8) | 1 (0.3) | 0.51 | 0.476 |
| Pericarditis | 1 (0.8) | 2 (0.6) | 0.05 | 0.821 |
| Heart failure | 5 (3.9) | 14 (4.2) | 0.01 | 0.905 |
| Cerebrovascular accident | 3 (2.4) | 7 (2.1) | 0.03 | 0.859 |
| Acute kidney injury, % | 26 (20.6) | 93 (28.0) | 2.58 | 0.108 |
| Acute kidney injury needing dialysis, % | 6 (4.7) | 15 (4.5) | 0.01 | 0.911 |
| Secondary intervention rate, % | ||||
| Chest tube (bedside) | 7 (5.5) | 17 (5.1) | 0.03 | 0.852 |
| Radiological intervention | 10 (7.9) | 54 (16.2) | 5.26 | 0.022 |
| Endoscopic intervention | 21 (16.6) | 48 (14.4) | 0.35 | 0.556 |
| Median length of stay | ||||
| Intensive care unit (hour) | 75.9±6.4 | 74.8±6.7 | 1.62 | 0.105 |
| Hospital (days) | 12.7±3.1 | 12.1±2.9 | 1.88 | 0.060 |
| Readmission rate, % | ||||
| Intensive care unit | 20 (15.9) | 68 (20.4) | 1.25 | 0.264 |
| Hospital | 16 (12.6) | 47 (14.1) | 0.16 | 0.686 |
| Leak-related reoperation, % | 5 (4.0) | 10 (3.0) | 0.26 | 0.608 |
| Mortality, % | ||||
| In-hospital | 4 (3.2) | 10 (3.0) | 0.01 | 0.928 |
| 30 day all-cause mortality | 5 (3.9) | 12 (3.6) | 0.03 | 0.858 |
| 30 day leak-cause mortality | 2 (1.6) | 4 (1.2) | 0.10 | 0.748 |
Values are expressed as mean±SD or number of patients (n, %).
P value refers to comparison between patients with COA and IOA.
COA, cervical oesophagogastric anastomosis; IOA, intrathoracic oesophagogastric anastomosis; MACCE, major adverse cardiovascular and cerebrovascular events.