Figure 1.

Coding of the characteristics of electronic healthcare databases available in Europe for the benefit–risk evaluation of medicines. The coding system was binary: 0 if information was absent and 1 if it was present. The degree of completion for a specific variable was not recorded. An exception to the binary classification was done for the accessibility variable: 0, no access; 1, indirect access through database owner or third party; 2, direct access to specific data sources; 3, direct access to full data source.