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. 2018 Aug 9;3(15):e120941. doi: 10.1172/jci.insight.120941

Figure 4. Lack of Muc5ac suppresses Kras-induced lung tumorigenesis.

Figure 4

(A) Histopathological appearance of lung tissue and (B) lung surface tumor number in CC-LR/Muc5ac+/+ and CC-LR/Muc5ac–/– mice at 14 weeks age (n = 12 CC-LR/Muc5ac+/+; n = 26 CC-LR/Muc5ac–/– mice). Ki-67 (C and D) and ERG (E and F) positive cells in lung tissue of CC-LR/Muc5ac+/+ and CC-LR/Muc5ac–/– mice at the age of 14 weeks (n = 3 per genotype). Data in B, D, and F are mean ± SEM. P < 0.05 by 2-tailed t test. Scale bars: 200 μm in A and 50 μm in C and E.