Figure 3. Ivacaftor-induced changes in sweat Cl– concentration correlate with changes in forced expiratory volume in 1 second and airway surface liquid pH.
(A) Relationship between changes in sweat Cl– concentration and changes in forced expiratory volume in 1 second (FEV1%) (P = 0.034 Spearman rank correlation, 0.46 correlation coefficient, n = 22). (B) Relationship between changes in sweat Cl– concentration and changes in airway surface liquid (ASL) pH (P = 0.038 Spearman rank correlation, 0.45 correlation coefficient, n = 21). (C) Relationship between changes in ASL pH and changes in FEV1% (P = 0.132 Spearman rank correlation, 0.34 correlation coefficient, n = 21).