Figure 8. Vascular consequences in SUR2^wt/AV mice.

(A) Representative blood pressures in anesthetized mice showing decreased basal pressures in SUR2^wt/AV and SUR2^AV/AV mice and blunted response to the K_ATP channel activator pinacidil. (B) Telemetric measurements of mean arterial pressure from ambulatory WT (black), SUR2^wt/AV (orange), and SUR2^AV/AV (red) mice show decreased blood pressure in SUR2^AV/AV mice (n = 3 for each genotype). (C) Summary data showing basal and pinacidil-reduced systolic (left) and diastolic (right) pressures from anesthetized WT, SUR2^wt/AV, and SUR2^AV/AV mice (n = 6 for WT, 5 for SUR2^wt/AV, and 6 for SUR2^AV/AV). (D) Isolated descending thoracic aortae show progressive dilation in SUR2^wt/AV and SUR2^AV/AV mice. (E) Aortic diameter derived from 2D sagittal echocardiographic imaging at different points around the aortic arch in WT (black), SUR2^wt/AV (orange), and SUR2^AV/AV (red). STJ, sinotubular junction; AA, ascending aorta; Arch, aortic arch; DA, descending aorta; as shown in inset; n = 3 each). (F) Vessel compliance in pressurized carotid arteries of WT (black), SUR2^wt/AV (orange), and SUR2^AV/AV (red) mice reveal increased diameters in mutant mice across full pressure range (n = 4 for WT, 5 for SUR2^wt/AV, and 5 for SUR2^AV/AV). Statistical significance was determined by multiway ANOVA followed by t test pairwise comparison with Bonferroni’s correction for multiple comparisons. Adjusted α = 0.008 (B), 0.006 (C), and 0.004 (F). **P < 0.01.