Skip to main content
. 2018 Aug 9;3(15):e121017. doi: 10.1172/jci.insight.121017

Figure 4. Radiation induces DNA damage only in BCA SMCs but does not result in increased apoptosis or proliferation.

Figure 4

(A and B) Lethal radiation exposure results in significantly more TUNEL+YFP+ cells within the brachiocephalic artery (BCA) at day 1 and 4 after radiation. (C–E) SMCs do not show increased TUNEL+ cells in the media of the coronary (C), aortic root (D), or pulmonary vessels (E). (F) There was no difference in the number of YFP+ cells in the media of the BCA. (G) There was no difference in the number of cleaved caspase-3+YFP+ cells in the media of the BCA. (H) Nor was there any change in the number of cells incorporating BrdU following lethal radiation exposure. Data were assessed by Mann Whitney U test. Data represent mean ± SEM. Sample number is indicated in the graph. Scale bar: 25μm.