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. 2018 Aug 9;3(15):e98720. doi: 10.1172/jci.insight.98720

Figure 2. Dapagliflozin limits glomerular structural lesions and inflammation in mice with protein overload.

Figure 2

(A) Periodic acid–Schiff–stained images of representative glomeruli from control mice (n = 5) and in BSA-mice treated with vehicle, dapagliflozin (DAPA), or ACE inhibitor (ACEi) (n = 8 each group). The overall glomerular damage score was calculated by summing mesangial matrix expansion (arrow), glomerular capillary dilation (asterisks), and adhesions of the glomerular tuft to the Bowman’s capsule (arrowheads). Scale bars: 20 μm. (B) Glomerular and interstitial accumulation of Mac-2–positive monocytes/macrophages in control mice (n = 5) and in BSA-mice treated with vehicle, dapagliflozin, or ACE inhibitor (n = 8 each group). Data are the mean ± SEM and were analyzed by ANOVA with Tukey’s post hoc test.