Figure 3. Sex-specific associations between mutant p53 residual transcriptional activity and survival time after diagnosis of glioma and gastric adenocarcinoma.

(A) Kaplan-Meier survival curves of glioma patients and (B) gastric adenocarcinoma patients harboring sporadic TP53 mutations resulting in inactive mutant p53 (0% activity) versus those having mutations that retain transactivation function (>0% activity). (C and D) Kaplan-Meier survival curves of male patients stratified by a gradation of mutant p53 residual transcriptional activity (0% activity, >0%-to-<5% activity, and >5% activity) with glioma (C) and gastric cancer (D). (E and F) Kaplan-Meier survival curves of female patients stratified by a gradation of mutant p53 residual transcriptional activity (0% activity, >0%-to-<5% activity, and >5% activity) with glioma (E) and gastric cancer (F). Dotted lines indicate median survival times, and vertical lines on the Kaplan-Meier curves indicate patients who were censored. Two-sided P values were calculated using the log-rank test.