Figure 5. Lifetime cancer survival of germline TP53 mutation carriers stratified by their mutant p53 residual transcriptional activity scores.

(A and B) Kaplan-Meier survival curves of female (A) and male (B) patients grouped by those carrying p53 mutants with <25% versus >25% transcriptional activity relative to WT p53. (C) Kaplan-Meier survival curves of the male and female cohorts of germline TP53 mutation carriers. (D) Kaplan-Meier survival curves of patients (pooled male and female) subdivided by carriers of mutant p53 with <25% activity, >25%-to-<50% activity, and >50% activity. Dotted lines indicate median survival times, and vertical lines on the Kaplan-Meier curves indicate patients who were censored. Two-sided P values were calculated using the log-rank test. (E) Box and whiskers plots (10th–90th percentile) representing the age at first tumor onset according to the TP53 mutation activity group or R337H carriers (P value calculated using proportion test). (F) The frequency of brain and gastric tumors that occur in male versus female germline TP53 mutation carriers (data represents mean ± SEM; P value calculated using 2-tailed Student’s t test).