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. 2018 Aug 9;3(15):e121739. doi: 10.1172/jci.insight.121739

Figure 2. Transcriptome for PDE5-I and PDE9-I shows many changes but few overlapping ones.

Figure 2

Samples from the same cohort of mice from Figure 1 were analyzed by RNA-seq. (A) RNA-seq analysis revealed 234 shared genes between PDE5-I (Sil) and PDE9-I (PF-9613), with more genes changed overall by PDE9-I (1,756) than PDE5-I (868). (B) Correlation analysis of fold changes of the genes shared between PDE5-I and PDE9-I. (C) Gene numbers in KEGG pathways identified to be upregulated in PO compared with sham for PO, PO+PDE5-I, and PO+PDE9-I. (D) Gene numbers in KEGG pathways identified to be downregulated in PO compared with sham for PO, PO+PDE5-I, and PO+PDE9-I. Striped bars in the KEGG pathway graphs indicate pathways that are not significantly different from sham.