Figure 3.

(A) Three simulated single-channel current traces for a step depolarization $V_m$ from −80 to 60 mV. (B) The ensemble current (average of 100 traces) fits the experimental data (9). (C) An expanded section of a simulated single-channel trace is presented here. Experimentally identified current levels (9) (dashed lines, black entries) and SC computed from simulations (blue entries) are shown. (D) A current amplitude histogram of simulated single-channel traces at 60 mV (blue) and the corresponding experimental data (shaded gray) (9) is given. The arrow indicates the mean current amplitude histogram (0.47 pA, also indicated by the arrow in (E)). (E) Similar histograms (to (D)) are constructed for a range of $V_m$ to obtain the microscopic I-V relationship (blue line) that fits experimental data (symbols) with a slope (mean conductance) of 3.27 pS (as determined experimentally (9)).