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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2018 Jul 27;26(15):4518–4531. doi: 10.1016/j.bmc.2018.07.043

Figure 4. Compound 65 is an inverse agonist of hCB1.

Figure 4.

CHO-hCB1 cells were loaded with calcium indicator dye for 60 minutes as described in the “Experimental” section. Cells were then stimulated by various concentrations of 2 as control and 65 and the fluorescence change recorded using a FLIPR Tera (Molecular Devices) instrument. Vehicle only elicited no response. Data is reported as a Mean ± SEM from 3 independent measurements.