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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2018 Jul 27;26(15):4518–4531. doi: 10.1016/j.bmc.2018.07.043

Table 4.

Mouse PK Data for Compound 65

Structure PO
Dose
mg/kg		 Half-Lifea hours Plasma
Tmax
hours		 Max.
Plasma
Conc.
ng/mL		 Max.
Brain/
Plasma
graphic file with name nihms-1503214-t0041.jpg 2.5 6.1 4.0 500 0.18
a

Time points were: 1, 2, 4, 8 & 24 hours post-dosing.