Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2019 Sep 1.

Published in final edited form as: Mayo Clin Proc. 2018 Mar 16;93(9):1213–1223. doi: 10.1016/j.mayocp.2018.01.014

Table 4.

Net reclassification improvement analysis for incident cardiovascular events with addition of FH definitions to models adjusted for FRS in the entire study population and those at intermediate risk, respectively^a

FH Variable	CHD NRI (95%CI)	Composite ASCVD NRI (95%CI)
Total Population
FRS+ FH Any	0.162 (0.061,0.264)^b	0.166 (0.094,0.243)^b
FRS+ FH Premature	0.069 (−0.106,0.179)	0.076 (0.014,0.135)^b
FRS+ FH Risk Strata	0.164 (0.067,0.260)^b	0.165 (0.090,0.237)^b
Population at Intermediate Risk by FRS
FRS+ FH Any	0.160 (−0.200, 0.323)	0.143 (0.041, 0.244)^b
FRS+ FH Premature	0.064 (−0.190, 0.206)	0.036 (−0.108, 0.111)
FRS+ FH Risk Strata	0.159 (−0.201, 0.318)	−0.209 (−0.155, 0.205)

^a

ASCVD= atherosclerotic cardiovascular disease, CHD = coronary heart disease, FH = family history, FRS = Framingham Risk Score, NRI = net reclassification index.

^b

Indicated statistically significant results.