Table 2.
Association between MnSOD, CAT, and GPx1 genotypes and risk of coronary artery disease.
| Genotype | Cases, n (%) N=447 | Controls, n (%) N=210 | OR(95% CI)a | P-value |
|---|---|---|---|---|
| MnSOD Val-9Ala | ||||
| Val/Val | 352(78.7) | 181(86.2) | 1.00 | |
| Val/Ala | 83(18.6) | 27(12.9) | 1.82(1.10-2.99) | 0.019 |
| Ala/Ala | 12(2.7) | 2(0.9) | 2.40(0.51-11.3) | 0.269 |
| P for trend | 0.012 | |||
| Val/Val | 352(78.8) | 181(86.2) | 1.00 | |
| Val/Ala+Ala/Ala | 95(21.2) | 29(13.8) | 1.86(1.15-3.01) | 0.011 |
| CAT C-262T | ||||
| C/C | 403(90.2) | 197(93.8) | 1.00 | |
| C/T | 42(9.4) | 13(6.2) | 1.43(0.73-2.82) | 0.299 |
| T/T | 2(0.5) | 0(0.0) | — | 0.982 |
| C/C | 403(90.2) | 197(93.8) | 1.00 | |
| C/T+T/T | 44(9.8) | 13(6.2) | 1.51(0.77-2.95) | 0.233 |
| GPx1 Pro198Leu | ||||
| Pro/Pro | 406(90.8) | 191(90.9) | 1.00 | |
| Pro/Leu | 41(9.2) | 19(9.1) | 1.08(0.58-1.99) | 0.817 |
a: adjusted for age, sex, cigarette smoking, and alcohol drinking.