Fig. 8. Effect of M. vaccae on stress-induced HMGB1.
Animals received 3 injections of either vehicle or M. vaccae (0.1 mg, s.c.). Seven d after the third injection, animals were exposed to stress (IS; inescapable tailshock) or served as home cage controls (HCCs). Twenty-four h post-IS, hippocampal HMGB1 protein levels were measured. N = 9–12 animals per group. Data are presented as the mean + s.e.m. The vehicle/IS treatment group significantly differed from all other treatment groups, ** p < 0.01.