Table 5.

Energetic Cost of the Point Mutation and Loop Extensions in a Two-Repeats Array of CTPRs

	$\mathit{\Delta \Delta }{G}_{D-N}^{H_{2}O}$ (kcal mol−1)
Cost of YD mutation in CTPR2n	2.6 ± 0.1
Cost of RS loop instead of NN loop	1.0 ± 0.1
Cost of loop10 in CTPR2-YD	1.8 ± 0.1
Cost of loop25 in CTPR2-YD	2.2 ± 0.1
Cost of loop10 in CTPR2	1.7 ± 0.1
Cost of loop25 in CTPRn	2.3 ± 0.1
Theoretical entropic cost of a loop10a	1.1
Theoretical entropic cost of a loop25a	1.7

$\mathit{\Delta \Delta }{G}_{D-N}^{H_{2}O}$ values are calculated as the difference in $\mathit{\Delta }{G}_{D-N}^{H20}$ between the specified proteins. Errors were propagated from the errors obtained from the fitted variables.

^aThe theoretical entropic cost of both loop lengths.