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ONC201 synergized with paclitaxel in USC cells. The ARK1 (A) and SPEC-2 (B) cells were pretreated with ONC201 (0.5 uM) for 24 hours and then treated with different concentrations of paclitaxel for 48 hours. MTT assays showed that ONC201 increased sensitivity to paclitaxel in both cell lines. Combination index (CI) was calculated by Chou-Talalay method (C) supported by CompuSyn.
