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. 2018 Aug 1;8(8):1414–1426.

Figure 4.

Figure 4

GAS5 regulates the expression of miR-223. A. The binding site between GAS5 and miR-223 was predicted. B. Luciferase activity of reporters containing the GAS5-WT or GAS5-MUT sequence in 786-O cells transfected with the miR-223 mimic or mimic negative control (mim-NC). C. Effects of GAS5 knockdown on the expression of miR-223. D. The expression of GAS5 in ccRCC cells transfected with the miR-223 mimic or inhibitor. E. The expression of GAS5 was reduced in tumors compared with that in nontumor tissues. F. Pearson correlation analysis was performed to detect the relationship between GAS5 and miR-223 in cancer tissues. inh-NC, inhibitor negative control; NT, nontumor tissues; *P<0.05; ***P<0.001.