Figure 1.

Reported spectrum of significantly mutated driver genes in pediatric and adult cancers. A. Most common recurrently mutated genes in adult cancers. B. Most common recurrently mutated genes in pediatric cancers. Different types of cancers are denoted by different colors, and the frequency (%) of the mutated gene in each cancer is represented by the upper margin of the respective cancer. For each bar/mutated gene the top four tumors with recurrence of the mutated gene are depicted. Mutated genes in blue represent common recurrently mutated genes in both pediatric and adult cancers. Data for the significantly mutated genes in adult and pediatric cancer were retrieved from cBioPortal for Cancer Genomics [249,250] and St. Jude Cloud PeCan, respectively.