Table 1.
Summary of currently approved targeted therapy for adult cancers and their respective targets
| Target Gene | Drug | Type of cancer |
|---|---|---|
| C-Kit | Imatinib | Gastrointestinal stromal cancers |
| EGFR | Erlotinib | Non-small cell lung carcinoma (NSCLC) |
| Gefitinib | Non-small cell lung carcinoma (NSCLC) | |
| Panitumumab/cetuximab | Colorectal cancer (CRC) | |
| EML4-ALK | Crizotinib | Non-small cell lung carcinoma (NSCLC) |
| BRAF | Vemurafenib | Melanoma |
| Sorafenib | Renal cell carcinoma | |
| Hepatocellular carcinoma | ||
| Thyroid carcinoma | ||
| MEK | Trametinib | Melanoma |
| Non-small cell lung carcinoma (NSCLC) | ||
| HER2 | Trastuzumab | Breast cancer |
| Gastric cancer | ||
| Esophageal cancer | ||
| CDK4/6 | Palbociclib | Breast cancer |