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. 2018 Aug 1;8(8):1483–1498.

Figure 3.

Figure 3

TOB1-AS1 inhibited cell growth and invasion. A. PCR assay was used to verify the expression of TOB1-AS1 in cells. B. Overexpression of TOB1-AS1 in HeLa cells suppressed proliferation, while knockdown of TOB1-AS1 promoted proliferation of C33A cells. C. Upregulation of TOB1-AS1 induced cell cycle arrest at G1 phase; Silencing of TOB1-AS1 promoted cell cycle progression from G1 phase to S phase. D. Apoptotic cells were increased by pcTOB1-AS1 and decreased by si-RNA1 and si-RNA2. E. The invasion ability were assayed using the transwell assay in HeLa and C33A cells. pcDNA3.1, negative control; pcTOB1-AS1, TOB1-AS1 expressing plasmid; si-ctrl, siRNA control; si-RNA1/2, siRNAs for knocking down TOB1-AS1. *P<0.05; **P<0.01.