Table 4.
Predictive target genes of miR-34a with GO analysis
| GO ID | GO term | Count (%) | Gene symbol | P-value |
|---|---|---|---|---|
| Biological process | ||||
| GO:0030574 | Collagen catabolic process | 5 | COL4A1, MMP19, COL12A1, ADAMTS2, COL10A1 | 1.90E-04 |
| GO:0000082 | G1/S transition of mitotic cell cycle | 5 | CCNE1, MCM8, CDK4, CDK2, ACVR1 | 0.001121 |
| GO:0042127 | Regulation of cell proliferation | 6 | CHST11, TGFB3, EGLN3, CXCL9, BRCA1, CXCL10 | 0.001423 |
| GO:0000724 | Double-strand break repair via homologous recombination | 4 | MCM8, BRCA1, FEN1, RAD51 | 0.004420 |
| GO:0006260 | DNA replication | 5 | MCM8, KIAA0101, BRCA1, FEN1, CDK2 | 0.005108 |
| GO:0032757 | Positive regulation of interleukin-8 production | 3 | DDX58, SERPINE1, FADD | 0.005968 |
| GO:0051607 | Defense response to virus | 5 | IFIT3, CXCL9, FADD, GBP1, CXCL10 | 0.006360 |
| GO:0045893 | Positive regulation of transcription, DNA-templated | 8 | CCNE1, TGFB3, ROR2, FOXP3, BRCA1, CDK2, RUNX3, ACVR1 | 0.008061 |
| GO:1902042 | Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 3 | SERPINE1, FADD, BRCA1 | 0.009503 |
| GO:0045859 | Regulation of protein kinase activity | 3 | CCNE1, CDK4, CXCL10 | 0.010068 |
| Cellular component | ||||
| GO:0031012 | Extracellular matrix | 9 | TUBB, COL4A1, LTBP2, MMP19, SERPINE1, TGFB3,etc | 2.89E-05 |
| GO:0005576 | Extracellular region | 18 | COL4A1, ADAM23, MMP19, CXCL9, FGF11, TGFB3, etc | 2.34E-04 |
| GO:0000307 | Cyclin-dependent protein kinase holoenzyme complex | 3 | CCNE1, CDK4, CDK2 | 0.001695 |
| GO:0005578 | Proteinaceous extracellular matrix | 6 | LTBP2,MMP19, LOX, ADAMTS12, ADAMTS2, COL10A1 | 0.004950 |
| GO:0005788 | Endoplasmic reticulum lumen | 5 | COL4A1, FKBP14, COL12A1, CTSC, COL10A1 | 0.008112 |
| GO:0097134 | Cyclin E1-CDK2 complex | 2 | CCNE1, CDK2 | 0.008214 |
| GO:0000139 | Golgi membrane | 8 | KDELR3, ECE2, CHST11, GPSM1, CTSC, ABCG1, GBP1, AGTRAP | 0.010775 |
| GO:0009897 | External side of plasma membrane | 5 | CXCL9, FCER1G, ANTXR2, ABCG1, CXCL10 | 0.011557 |
| GO:0005615 | Extracellular space | 12 | UCN2, LTBP2, SULF2, SERPINE1, TGFB3, CXCL9, COL12A1, etc | 0.021426 |
| GO:0005829 | Cytosol | 22 | POLR2H, PRTFDC1, GMNN, EGLN3, TRIO, FADD, CDK4, etc | 0.024066 |
| Molecular function | ||||
| GO:0004222 | Metalloendopeptidase activity | 5 | ECE2,ADAM23,MMP19, ADAMTS12, ADAMTS2 | 0.001380 |
| GO:0005515 | Protein binding | 51 | LTBP2, DZIP1, TGFB3, SENP5, CXCL10,CCNE1,MCM8, etc | 0.001986 |
| GO:0042802 | Identical protein binding | 10 | DDX58, IFIT3, STK10, TGFB3, RIPK2, CTSC, FADD, etc | 0.004431 |
| GO:0004674 | Protein serine/threonine kinase activity | 7 | STK10, TRIO, RIPK2, CDK4, NEK6, CDK2, ACVR1 | 0.005327 |
| GO:0005524 | ATP binding | 14 | STK10, TRIO, CDK4, CDK2, ABCG1, RAD51, EPHB2,etc | 0.009935 |
| GO:0048248 | CXCR3 chemokine receptor binding | 2 | CXCL9, CXCL10 | 0.021147 |
| GO:0003690 | Double-stranded DNA binding | 3 | DDX58, FEN1, RAD51 | 0.046830 |
Notes: Only top 10 was were presented in the table.