HD prevented the development of diabetes in db/db mice. A-D. Body weight, water intake, food intake and blood glucose, and were higher in the db/db group than in the db/m group during the study, during the 14-week observation period. **P < 0.001, compared with the db/m group; #P < 0.05, ##P < 0.001, compared with the db/db group (n = 10).