Figure 2.

Ankle joint histology from hind paws of CIA rats. Rats were sacrificed on day 36 and two back paws of each rat were collected to be made into tissue paraffin section which were then stained with H&E for microscopic photography. Scale bar = 500 μm. (A-E) Representative tissue sections of control, model, HOEC 1 mg/kg, HOEC 3 mg/kg and HOEC 10 mg/kg treatment groups; (F) Details of red box in (B), where s is synovial; cis cartilage, m is meniscus, bm is bone marrow, p is pannus, and arrow is cartilage destruction. HOEC can reduce damage of joint tissue caused by arthritis, but the effect was weaker in high dose than low and middle doses.