4.

Differences in texture features in shape and morphology metrics category between each pair of groups of preinvasive lesions, MIAs and IPAs

Texture features	P value
	Preinvasive lesions vs. MIAs	Preinvasive lesionsvs. IPAs	MIAs vs. IPAs
MIAs, minimally invasive adenocarcinomas; IPAs, invasive pulmonary adenocarcinomas; Volume cc, volume in cubic centimeters; *, statistical analysis using analysis of variance (ANOVA) followed by Tukey’s HSD post hoc test, otherwise using a Kruskal-Wallis rank sum test followed by Dunn-Bonferroni post hoc test.
Volume (mm3)	>0.05	0.001	<0.001
Surface area (mm2)	>0.05	0.002	<0.001
Surface: volume ratio	>0.05	0.008	<0.001
Compactness 1	>0.05	0.002	<0.001
Compactness 2	>0.05	0.012	0.045
Spherical disproportion	>0.05	0.001	<0.001
Sphericity	>0.05*	0.007*	0.038*
Maximum 3D diameter	>0.05	0.001	<0.001
Volume cc	>0.05	0.001	<0.001