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. 2018 Sep 3;12:276. doi: 10.3389/fncel.2018.00276

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Copyright © 2018 Laing, Li, Schmidt, Bunner, Yuan, Landry, Prete, McClung and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Group I metabotropic receptor agonist dihydroxyphenylglycine (DHPG) enhances firing rate of NPY/AgRP neurons specifically under the fasted condition. (A) Representative trace showing neuronal firing of AgRP/NPY neuron from a fed mouse under aCSF and DHPG. (B) Representative trace showing neuronal firing of AgRP/NPY neuron from fasted mouse under aCSF (middle left) and DHPG (middle right). (C) Bar graph (bottom left) of mean firing rate and (D) dot plot of each individual neuron (bottom right). Standard t-test used to compare across fed and fasted conditions, matched pairs t-test used for detection of within condition differences. Means ± SEM (n = 11 fed; n = 12 fasted). Bar graph significance marked by *p < 0.05.