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. 2018 Sep 3;12:276. doi: 10.3389/fncel.2018.00276

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Copyright © 2018 Laing, Li, Schmidt, Bunner, Yuan, Landry, Prete, McClung and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A subset of AgRP/NPY neurons under synaptic blockade exhibit a slow inward current in response to group I metabotropic receptor agonist DHPG. (A) Representative whole cell voltage clamp recording of an AgRP/NPY neuron that does not respond to DHPG. (B) Representative whole cell voltage clamp recording of an AgRP/NPY neuron in response to DHPG. (C) Bar graph of proportion of AgRP/NPY neurons from fasted mice that are DHPG responders (4/16). (D) Bar graph of current change from previous condition. Matched pair t-test to compare blockade and blockade + DHPG conditions. Means ± SEM (n = 4). Bar graph significance marked by *p < 0.05.