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mGluR1 antagonist 3-MATIDA slows firing rate of NPY/AgRP neurons from fasted mice. (A) Representative whole cell recordings of neuronal firing of AgRP/NPY neuron from a fed mouse under aCSF and 3-MATIDA. (B) Bar graph of mean firing rate. (C) Dot plot of each individual neuron. Matched pair t-test used to compare across fed and fasted conditions. Means ± SEM (n = 11). Bar graph significance marked by *p < 0.05.
