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. 2018 Sep 3;9:1980. doi: 10.3389/fimmu.2018.01980

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Copyright © 2018 Scalerandi, Peinetti, Leimgruber, Cuello Rubio, Nicola, Menezes, Maldonado and Quintar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Androgens augment LPS-induced, neutrophil-specific chemokine mRNA expression. (A–B) Rats were orchidectomized (OX) and treated with testosterone 2 mg/kg/day (T) before being inoculated with 1 mg of LPS intraprostatically for 24 h. Cell sorting was carried out to isolate Gr (+) neutrophils from prostatic cells and mRNA expression was evaluated by qPCR. (A) Testosterone treatment promotes an increase in CXCL1 and CXCL2 in prostatic cells. (B) Neutrophils exhibit a similar behavior, with no changes in Monocyte Chemoattractant Protein-1 (MCP1), the key chemokine regulating migration of monocytes/macrophages. (C) LPS-induced peritoneal neutrophils from testosterone-treated animals (T) showing an increase in CXCL1 and CXCL2. In all cases, the mRNA levels are relative to those of ACTB. Mean ± SEM, each dot represents one animal. *p < 0.05; **p < 0.01.