Table 3.
Individual data of AA level in six patients measuring AA level (n = 6)
| Patient no. | AAI, mg/kg | AAII, mg/kg | Prescribed duration, day | Cumulative AAI, mg/kg |
|---|---|---|---|---|
| 1a | 10.1 | 1.3 | 10 | 100.6 |
| 2a | 4,357.0 | 147.3 | 14 | 60,998.0 |
| 3 | 1.9 | 2.7 | UK | UK |
| 4a | 8,020.0 | 740.0 | 120 | 962,400.0 |
| 5 | 4.9 | ND | 14 | 67.9 |
| 6a | 26.4 | ND | 35 | 924.0 |
Note that the amount of AA contained in herbal remedies is not consistent, and the amount of exposure to patients is diverse.
AA, aristolochic acid; AAI, 8-methoxy-6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid; AAII, 6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid; UK, unknown; ND, not detected.
a
Patients with progression to end stage renal disease are indicated by a star.