Table 4.
Logistic regression analysis for risk factors of lower extremity amputation
| Variable | Multivariable analysis |
|
|---|---|---|
| Odds ratio (95% CI) | p value | |
| Age | 1.01 (0.96–1.06) | 0.798 |
| Smoking | 0.76 (0.19–3.03) | 0.694 |
| Hypertension | 0.57 (0.18–1.87) | 0.355 |
| Prior amputation history | 2.03 (0.33–12.53) | 0.445 |
| eGFR | 1.00 (0.99–1.01) | 0.915 |
| PAD | 4.39 (1.33–14.55) | 0.016 |
| Wound size, cm2 | ||
| < 10 | 1.00 | |
| 10 to < 25 | 0.52 (0.14–1.89) | 0.320 |
| ≥ 25 | 1.91 (0.43–8.45) | 0.392 |
| Bone or joint involvement of DFU | 3.74 (1.10–12.70) | 0.035 |
| Combined infection of DFU | 11.39 (2.55–50.93) | 0.001 |
CI, confidence interval; eGFR, estimated glomerular filtration rate; PAD, peripheral artery disease; DFU, diabetic foot ulcer.