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. 2018 Sep 3;12:52. doi: 10.3389/fninf.2018.00052

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Copyright © 2018 Xu, Liu, Zhan, Ren and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The altered functional connectivity drawn within brain surfaces (P < 0.001, uncorrected). As shown in the figure, more abnormal FCs were found with the development of Alzheimer's disease. In the contrast of sAD and NC groups, decreased FCs (in cyan) were mainly found between medial frontal areas and bilateral middle temporal gyrus, between medial frontal areas and posterior cingulate gyrus, between bilateral caudate and occipital areas, between superior occipital cortex and bilateral pre-/postcentral gyrus, while increased FCs (in red) were mainly found between the left inferior frontal and the medial and dorsolateral frontal areas.