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. 2018 Aug 27;2018:3928572. doi: 10.1155/2018/3928572

Figure 2.

Figure 2

ML-1 containing drugs modulate the expression of inflammation associated genes. (a) Heatmap showing changes in the expression of immune response-associated genes in LNT-229 cells treated for 24 h with either ISCADOR Qu (ISC Qu), Aviscumine (Avi), or native ML-1 (ML-1; each 8 ng/m of ML) as determined by microarray analysis. (b) qRT-PCR analysis of genes that were found to be differentially expressed in treated LNT-229 cells (8 ng/ml; 24 h) as indicated in (a). GAPDH serves as reference (I: ISCADOR Qu, A: Aviscumine, M: native ML-1; means ± SD, n=3; Student's t-test compared to control; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 after Bonferroni correction for n pair comparisons).