Figure 4.

Adjuvant ISCADOR Qu therapy prolonged the survival of glioma bearing mice. (a) Differential expression of cytokines in the serum of VM/DK mice injected with ISCADOR Qu or PBS as a control as described in the Methods part (means ± SD, n=4 animals). (b) Treatment schema of SMA-560 glioma bearing VM/Dk mice: Day 0 (d₀) depicts tumor cell implantation, irradiation (flash), ISCADOR Qu (I), ISCADOR Qu + TMZ (T). (c) Median survival of treatment groups (n=7 to 8 animals per group; p-values were defined using the log-rank test after Bonferroni correction for n pair comparisons). (d) Kaplan Mayer survival curves of the sham, ISCADOR Qu, TMZ + irradiation, and combined treatment (ISC Qu + TMZ + irradiation) groups.