Table 1. Key inclusion and exclusion criteria from NETT.
| Inclusion criteria | Exclusion criteria |
|---|---|
| FEV1 ≤45% (FEV1 ≥15% if age >70 years) | FEV1 ≤20% and homogenous emphysema or DLCO ≤20% |
| TLC ≥100% | Prior sternotomy, LVRS, or lobectomy |
| RV ≥150% | Bulla ≥ 1/3rd of lung |
| Completion of pulmonary rehab program | LVEF ≤45% or MI within the prior 6 months |
| Nonsmoker for ≥4 months | Prednisone ≥20 mg/day; pulmonary hypertension; 6-MWD <140 meters |
NETT, National Emphysema Treatment Trial; DLCO, diffusion capacity for the lungs using carbon monoxide; FEV1, forced expiratory volume in one second; LVEF, left ventricular ejection fraction; LVRS, lung volume reduction surgery; MI, myocardial infarction; RV, residual volume; TLC, total lung capacity; 6-MWD, 6-minute walk distance.