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. 2018 Aug 27;2018:4783602. doi: 10.1155/2018/4783602

Figure 3.

Figure 3

SS-31 scavenged ROS from the root of mitochondria. (a, b) SS-31 administration repressed the production of intercellular ROS detected by DHE staining and subjected to fluorescence microscopy analysis. The mean relative fluorescence intensity was calculated. SS-31 treatment decreased the total ROS content compared with the vehicle group. n = 6 per group. (c) The mitochondrial ROS was detected by MitoSOX with the fluorospectrophotometer, and the production of mitochondrial ROS was significantly decreased after SS-31 administration. n = 6 per group. (d) 8-OHdG was the indicator of DNA oxidative impairment. SS-31 reduced the formation of 8-OHdG. n = 6 per group. (e) Prussian blue staining showed the iron overload cells were fewer in the SS-31 group compared with the vehicle group. Arrows showed the Prussian blue staining. n = 6 per group. Scale bar 50 μm. Data are presented as mean ± SEM; ∗∗P < 0.01, ∗∗∗P < 0.001 versus the sham group; ##P < 0.01, ###P < 0.001 versus the TBI + vehicle group.