Comparison of serum KL-6 concentration between the progressive group and the non-progressive group. FVC >50% group n=88, FVC <50% group n=244, an independent sample t-test was performed. KL-6 concentration was highly elevated in progressive compared with non-progressive period, P<0.001. “Progressive” meant over 10% decrease in %FVC or over 15% decrease in %DLCO. “Non-progressive” meant within 10% change of %FVC and within 15% change of %DLCO, or increase in %FVC or increase in %DLCO. KL-6, Klebs von den Lungen-6; FVC, forced vital capacity; DLCO, diffusion capacity for carbon monoxide.