Table 2. Characteristics of the patients and the density of tumor-infiltrating lymphocytes.

Variables	n	TILs (/mm2)	CCR4+ TILs (/mm2)
Age (years)
≥65	106	2,072±746	415±155
<65	74	2,223±916	406±142
P value		0.24	0.69
Gender
Male	83	2,078±834	429±140
Female	97	2,182±811	395±155
P value		0.40	0.12
Smoking history
Ever	87	2,081±854	428±150
Never	93	2,184±790	395±147
P value		0.40	0.14
Histological subtypesa
Lepidic predominant	103	2,072±723	398±142
Non-lepidic predominantb	77	2,217±935	428±158
P value		0.26	0.18
Tumor size (cm)
>2	65	2,182±804	448±158
≤2	115	2,107±833	390±140
P value		0.55	0.017
Nodal involvement
Yes	16	2,318±715	499±198
No	164	2,116±831	402±141
P value		0.30	0.075
Recurrence
Yes	25	2,065±813	477±167
No	155	2,145±825	400±144
P value		0.65	0.039

^a, adenocarcinoma in situ and minimally invasive adenocarcinoma were not included in the study; ^b, non-lepidic predominant subtypes: acinar, 39; papillary, 14; solid, 20; mucinous, 3; colloid, 1. TIL, tumor-infiltrating lymphocytes.