Table 3. Univariate analysis of recurrence-free survival and overall survival.

Variables	Overall survival			Recurrence-free survival
	HR (95% CI)	P value		HR (95% CI)	P value
Age: ≥65 vs. <65 years	2.72 (1.17–7.38)	0.024		2.13 (1.1–4.44)	0.027
Male vs. female	4.57 (2.03–11.62)	0.0001		3.26 (1.73–6.5)	0.0002
Never smoker vs. ever smoker	0.40 (0.17–0.86)	0.019		0.36 (0.18–0.68)	0.0016
Lepidic predominant vs. non-lepidic	0.29 (0.13–0.63)	0.0013		0.18 (0.08–0.35)	<0.0001
Tumor size >2 vs. ≤2 cm	2.03 (0.94–4.35)	0.061		1.97 (1.06–3.62)	0.026
pN1, N2 vs. pN0	5.58 (2.38–12.14)	<0.0001		8.71 (4.43–16.36)	<0.0001
CD8 high vs. low	0.64 (0.29–1.35)	0.24		0.83 (0.44–1.52)	0.54
CD4 high vs. low	1.49 (0.70–3.29)	0.3		1.27 (0.69–2.36)	0.44
Foxp3 high vs. low	0.95 (0.45–2.01)	0.9		0.56 (0.29–1.03)	0.065
CCR4 high vs. low	2.31 (1.07–5.37)	0.034		2.39 (1.28–4.68)	0.006

HR, hazard ratio; CI, confidence interval.