Table 4. Multivariate analysis of recurrence-free survival and overall survival.

Variables	Overall survival			Recurrence-free survival
	HR (95% CI)	P value		HR (95% CI)	P value
Age ≥65 vs. <65 years	3.78 (1.60–10.44)	0.0026		2.85 (1.44–6.07)	0.0027
Male vs. female	6.17 (2.55–17.03)	<0.0001		2.91 (1.49–6.02)	0.0018
Lepidic predominant vs. non-lepidic	0.45 (0.17–1.12)	0.084		0.25 (0.11–0.54)	0.0004
pN1, N2 vs. pN0	6.19 (2.35–15.92)	<0.0001		7.30 (3.42–15.31)	<0.0001
CD8 high vs. low	0.19 (0.08–0.46)	0.0001		0.28 (0.13–0.56)	0.0002
CCR4 high vs. low	2.24 (1.01–5.34)	0.049		2.20 (1.16–4.39)	0.017

HR, hazard ratio; CI, confidence interval.