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The forest pot and TSA of the odds ratio of high dose bevacizumab associated thromboembolism events. (A) OR of high dose bevacizumab associated thromboembolism events; (B) Z-curve did not cross the trial sequential monitoring boundary for hazard (red dotted curve) and did not reach the required sample size based on TSA (n=3,007), entering the area of hazard (above the upper red line). OR, odds ratio; CI, confidence interval; TSA, trial sequence analysis.
