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. 2018 Oct 1;20(Suppl 4):iv1–iv86. doi: 10.1093/neuonc/noy131

Table 13.

Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Children and Adolescents (Age 0-19 Years), Brain and Other Central Nervous System Tumors by Major Histology Grouping, Histology, and Sex, CBTRUS Statistical Report: NPCR and SEER, 2011-2015

Histology Total Male Female
5-Year Total Annual Average Rate 95% CI 5-Year Total Annual Average Rate 95% CI 5-Year Total Annual Average Rate 95% CI
Tumors of Neuroepithelial Tissue 15,742 3,148 3.82 3.77-3.88 8,488 1,698 4.04 3.95-4.12 7,254 1,451 3.60 3.52-3.69
Pilocytic astrocytoma 3,746 749 0.91 0.88-0.94 1,954 391 0.93 0.89-0.97 1,792 358 0.89 0.85-0.93
Diffuse astrocytoma 998 200 0.24 0.23-0.26 534 107 0.25 0.23-0.28 464 93 0.23 0.21-0.25
Anaplastic astrocytoma 405 81 0.10 0.09-0.11 220 44 0.10 0.09-0.12 185 37 0.09 0.08-0.11
Unique astrocytoma variants 511 102 0.12 0.11-0.14 290 58 0.14 0.12-0.15 221 44 0.11 0.10-0.13
 Malignant 247 49 0.06 0.05-0.07 141 28 0.07 0.06-0.08 106 21 0.05 0.04-0.06
 Non-Malignant 264 53 0.06 0.06-0.07 149 30 0.07 0.06-0.08 115 23 0.06 0.05-0.07
Glioblastoma 759 152 0.18 0.17-0.20 408 82 0.19 0.18-0.21 351 70 0.17 0.16-0.19
Oligodendroglioma 191 38 0.05 0.04-0.05 99 20 0.05 0.04-0.06 92 18 0.05 0.04-0.06
Anaplastic oligodendroglioma 28 6 0.01 0.00-0.01 - - - - - - - -
Oligoastrocytic tumors 105 21 0.03 0.02-0.03 50 10 0.02 0.02-0.03 55 11 0.03 0.02-0.04
Ependymal tumors 1,216 243 0.29 0.28-0.31 670 134 0.32 0.29-0.34 546 109 0.27 0.25-0.29
 Malignant 1,022 204 0.25 0.23-0.26 567 113 0.27 0.25-0.29 455 91 0.23 0.21-0.25
 Non-Malignant 194 39 0.05 0.04-0.05 103 21 0.05 0.04-0.06 91 18 0.04 0.04-0.05
Glioma malignant, NOS 2,799 560 0.68 0.66-0.71 1,412 282 0.67 0.64-0.71 1,387 277 0.69 0.65-0.73
Choroid plexus tumors 406 81 0.10 0.09-0.11 230 46 0.11 0.10-0.12 176 35 0.09 0.07-0.10
 Malignant 101 20 0.02 0.02-0.03 54 11 0.03 0.02-0.03 47 9 0.02 0.02-0.03
 Non-Malignant 305 61 0.07 0.07-0.08 176 35 0.08 0.07-0.10 129 26 0.06 0.05-0.08
Other neuroepithelial tumors 32 6 0.01 0.01-0.01 - - - - 27 5 0.01 0.01-0.02
 Malignant 27 5 0.01 0.00-0.01 - - - - 24 5 0.01 0.01-0.02
 Non-Malignant - - - - - - - - - - - -
Neuronal and mixed neuronal-glial tumors 1,787 357 0.43 0.41-0.45 987 197 0.47 0.44-0.50 800 160 0.40 0.37-0.43
 Malignant 89 18 0.02 0.02-0.03 54 11 0.03 0.02-0.03 35 7 0.02 0.01-0.02
 Non-Malignant 1,698 340 0.41 0.39-0.43 933 187 0.44 0.41-0.47 765 153 0.38 0.35-0.41
Tumors of the pineal region 212 42 0.05 0.04-0.06 104 21 0.05 0.04-0.06 108 22 0.05 0.04-0.06
 Malignant 174 35 0.04 0.04-0.05 92 18 0.04 0.04-0.05 82 16 0.04 0.03-0.05
 Non-Malignant 38 8 0.01 0.01-0.01 - - - - 26 5 0.01 0.01-0.02
Embryonal tumors 2,547 509 0.62 0.60-0.64 1,510 302 0.72 0.68-0.76 1,037 207 0.52 0.48-0.55
 Medulloblastoma c 1,617 323 0.39 0.38-0.41 1,027 205 0.49 0.46-0.52 590 118 0.29 0.27-0.32
 Primitive neuroectodermal tumor d 311 62 0.08 0.07-0.08 162 32 0.08 0.07-0.09 149 30 0.07 0.06-0.09
 Atypical teratoid rhabdoid tumor e 388 78 0.09 0.08-0.10 201 40 0.10 0.08-0.11 187 37 0.09 0.08-0.11
 Other embryonal histologies f 231 46 0.06 0.05-0.06 120 24 0.06 0.05-0.07 111 22 0.05 0.05-0.07
Tumors of Cranial and Spinal Nerves 1,286 257 0.31 0.29-0.33 672 134 0.32 0.29-0.34 614 123 0.30 0.28-0.33
Nerve sheath tumors 1,283 257 0.31 0.29-0.33 669 134 0.32 0.29-0.34 614 123 0.30 0.28-0.33
 Malignant 23 5 0.01 0.00-0.01 - - - - - - - -
 Non-Malignant 1,260 252 0.31 0.29-0.32 659 132 0.31 0.29-0.34 601 120 0.30 0.27-0.32
Other tumors of cranial and spinal nerves - - - - - - - - - - - -
Tumors of Meninges 1,116 223 0.27 0.25-0.28 551 110 0.26 0.24-0.28 565 113 0.28 0.26-0.30
Meningioma 668 134 0.16 0.15-0.17 318 64 0.15 0.13-0.17 350 70 0.17 0.15-0.19
 Malignant 33 7 0.01 0.01-0.01 - - - - 21 4 0.01 0.01-0.02
 Non-Malignant 635 127 0.15 0.14-0.16 306 61 0.14 0.13-0.16 329 66 0.16 0.14-0.18
Mesenchymal tumors 231 46 0.06 0.05-0.06 123 25 0.06 0.05-0.07 108 22 0.05 0.04-0.06
Primary melanocytic lesions - - - - - - - - - - - -
Other neoplasms related to the meninges 207 41 0.05 0.04-0.06 103 21 0.05 0.04-0.06 104 21 0.05 0.04-0.06
Lymphomas and Hematopoietic Neoplasms 121 24 0.03 0.02-0.04 79 16 0.04 0.03-0.05 42 8 0.02 0.01-0.03
Lymphoma 59 12 0.01 0.01-0.02 40 8 0.02 0.01-0.03 19 4 0.01 0.01-0.01
Other hematopoietic neoplasms 62 12 0.02 0.01-0.02 39 8 0.02 0.01-0.03 23 5 0.01 0.01-0.02
Germ Cell Tumors and Cysts 910 182 0.22 0.21-0.24 630 126 0.30 0.28-0.32 280 56 0.14 0.12-0.16
Germ cell tumors, cysts and heterotopias 910 182 0.22 0.21-0.24 630 126 0.30 0.28-0.32 280 56 0.14 0.12-0.16
 Malignant 708 142 0.17 0.16-0.19 525 105 0.25 0.23-0.27 183 37 0.09 0.08-0.11
 Non-Malignant 202 40 0.05 0.04-0.06 105 21 0.05 0.04-0.06 97 19 0.05 0.04-0.06
Tumors of Sellar Region 3,850 770 0.92 0.89-0.95 1,231 246 0.58 0.55-0.61 2,619 524 1.28 1.24-1.33
Tumors of the pituitary 3,002 600 0.72 0.69-0.74 798 160 0.37 0.35-0.40 2,204 441 1.08 1.03-1.12
 Malignant - - - - - - - - - - - -
 Non-Malignant 2,999 600 0.72 0.69-0.74 797 159 0.37 0.35-0.40 2,202 440 1.08 1.03-1.12
Craniopharyngioma 848 170 0.21 0.19-0.22 433 87 0.21 0.19-0.23 415 83 0.21 0.19-0.23
Unclassified Tumors 1,507 301 0.36 0.35-0.38 719 144 0.34 0.32-0.37 788 158 0.39 0.36-0.42
Hemangioma 599 120 0.14 0.13-0.16 284 57 0.13 0.12-0.15 315 63 0.16 0.14-0.17
Neoplasm, unspecified 882 176 0.21 0.20-0.23 423 85 0.20 0.18-0.22 459 92 0.23 0.21-0.25
 Malignant 212 42 0.05 0.04-0.06 109 22 0.05 0.04-0.06 103 21 0.05 0.04-0.06
 Non-Malignant 670 134 0.16 0.15-0.17 314 63 0.15 0.13-0.17 356 71 0.18 0.16-0.20
All other 26 5 0.01 0.00-0.01 - - - - - - - -
TOTAL g 24,532 4,906 5.94 5.87-6.02 12,370 2,474 5.87 5.77-5.98 12,162 2,432 6.02 5.91-6.13
  Malignant 14,422 2,884 3.51 3.45-3.56 7,902 1,580 3.76 3.68-3.84 6,520 1,304 3.24 3.16-3.32
  Non-Malignant 10,110 2,022 2.44 2.39-2.49 4,468 894 2.11 2.05-2.18 5,642 1,128 2.78 2.71-2.85

aAnnual average cases are calculated by dividing the five-year total by five.

bRates are per 100,000 and are age-adjusted to the 2000 US standard population.

cICD-O-3 histology and behavior codes: 9470/3, 9471/3, 9472/3, and 9474/3.

dICD-O-3 histology and behavior code: 9473/3.

eICD-O-3 histology and behavior code: 9508/3.

fICD-O-3 histology and behavior codes: 8963/3, 9364/3, 9480/3, 9490/0, 9490/3, 9500/3, 9501/3, and 9502/3.

gRefers to all brain tumors including histologies not presented in this table.

- Counts and rates are not presented when fewer than 16 cases were reported for the specific histology category. Suppressed cases are included in the total counts and rates.

Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified