Figure 3:

The cellular homeostasis system in P. canaliculata. The unfolded protein response (UPR) system includes HSPs and HSF in the heat shock response and CNX, NEF, GRP94, BIP, HSP40, ATF6, IRE1, PERK, COP2, XBP, ATF4, TRAM, and Derlin in the endoplasmic reticulum unfolded protein response (UPR-ERAD). Apoptotic pathways include XIAPs, Bcl2, caspases, TNFR, and FADD. The antioxidant systems include PRX, SOD, CAT, and GPX. The xenobiotic biotransformation system includes EPHX3, P450, FMO, and ABC transporter. The colors of the boxes for gene families represent the degree of upregulation (FPKM-stimulus/FPKM-control) as an overall result of stress, including heat, cold, heavy metal, and air exposure. Pathways and genes were obtained based on KEGG annotation.